此研究由愛荷華大學醫學院家庭醫學部和威斯康辛大學醫學院家庭社區部所發表，作者是Bentler
SE, Hartz AJ, Kuhn EM.，發表於臨床精神病治療期刊。
抱怨無法解釋的慢性疲勞，在主要的醫療照護中是經常聽到的。這實驗設計是評估某些用來治療慢性疲勞的療法是否有效。
這是原文和翻譯軟體翻的怪怪文章，大致上是說，找了一百多個有不明原因慢性疲勞的人，來嘗試幾個療法，有維他命，補品，活力運動，鎂(怪怪，鎂能吃嗎？)，瑜珈，支持團體，最後得到一個結論，瑜珈是裡頭最有效的，並且建議值得在以隨機控制組的方式實驗。
背景︰ 不能解釋的慢性疲勞是在最初保健護理過程中的頻繁的抱怨。
一種預期的觀察研究設計用來評價是否不能解釋的慢性疲勞的一定通常使用的治療可能有效。
方法︰
有未知的病原學的不能解釋的慢性疲勞的學科至少6個月被從偉玆康辛州慢性疲勞綜合症協會招募，
最初保健護理門診部和社區慢性疲勞綜合症贈送。
主要結果議案在一5個問題疲勞得分從6 月在2年內改變。
自我報告的干涉測試包括的開的藥物，非處方的補充和藥草，生活模式改變，其它的治療和心理支持。
線性回歸分析用來測試在據統計調整以求顯著的預測的原素之后，有結果的每次治療的協會測量。
結果︰ 155個主題提供關於在基線的疲勞和治療的訊息和后續。
在這些主題中，87%是女性的，79%中年。 疲勞的中間的持續時間是6.7
年。 發現一種處理方法有幫助的用戶的百分比最對coenzyme
Q10大有好處(13個主題中的69%)，
dehydroepiandrosterone(DHEA)(17個主題中的65%)，以及人參(18個主題中的56%)。
在預言隨后的疲勞改進的6個月的治療是維生素(便士 = .
08),有力的練習(便士 = . 09),並且瑜珈(便士 = .
002). 鎂(便士 = . 002)並且支持組(便士 = .
06)強烈與從6個月惡化到2 年的疲勞相關。
瑜珈看起來對於主題非常有效沒讓人把不清楚的思想與疲勞相關。 結論︰
適合不能解釋慢性疲勞肯定其它治療，特別是瑜珈，應有測試在隨機化排列控制的審訊。
Prospective observational study of
treatments for unexplained chronic
fatigue.
Bentler SE, Hartz AJ, Kuhn EM.J Clin
Psychiatry. 2005 May;66(5):625-32.
From the Department of Family
Medicine, College of Medicine,
University of Iowa, Iowa City (Ms.
Bentler and Dr. Hartz); and the
Department of Family & Community
Medicine, Medical College of
Wisconsin, Milwaukee (Dr. Kuhn).
BACKGROUND: Unexplained chronic
fatigue is a frequent complaint in
primary care. A prospective
observational study design was used
to evaluate whether certain commonly
used therapies for unexplained
chronic fatigue may be effective.
METHOD: Subjects with unexplained
chronic fatigue of unknown etiology
for at least 6 months were recruited
from the Wisconsin Chronic Fatigue
Syndrome Association, primary care
clinics, and community chronic
fatigue syndrome presentations. The
primary outcome measure was change
in a 5-question fatigue score from 6
months to 2 years. Self-reported
interventions tested included
prescribed medications,
non-prescribed supplements and
herbs, lifestyle changes,
alternative therapies, and
psychological support. Linear
regression analysis was used to test
the association of each therapy with
the outcome measure after adjusting
for statistically significant
prognostic factors. RESULTS: 155
subjects provided information on
fatigue and treatments at baseline
and follow-up. Of these subjects,
87% were female and 79% were
middle-aged. The median duration of
fatigue was 6.7 years. The
percentage of users who found a
treatment helpful was greatest for
coenzyme Q10 (69% of 13 subjects),
dehydroepiandrosterone (DHEA) (65%
of 17 subjects), and ginseng (56% of
18 subjects). Treatments at 6 months
that predicted subsequent fatigue
improvement were vitamins (p = .08),
vigorous exercise (p = .09), and
yoga (p = .002). Magnesium (p =
.002) and support groups (p = .06)
were strongly associated with
fatigue worsening from 6 months to 2
years. Yoga appeared to be most
effective for subjects who did not
have unclear thinking associated
with the fatigue. CONCLUSION:
Certain alternative therapies for
unexplained chronic fatigue,
especially yoga, deserve testing in
randomized controlled trials.